Vericef 100 ml PFS

Vericef (Cefradine) Capsules and Oral Suspension are indicated in the treatment of the following infections when caused by susceptible strains of the designated microorganisms:

• Upper respiratory tract infections – sinusitis, pharyngitis, tonsillitis, laryngotracheo bronchitis and otitis media.
• Lower respiratory tract infections – acute and chronic bronchitis, lobar and bronchopneumonia.
• Urinary tract infections – cystitis, urethritis and pyelonephritis.
• Skin and soft tissue infections – impetigo, abscess, cellulitis, furunculosis.

Vericef 500 mg capsules are also used in the prophylaxis of postoperative infections following surgical procedures associated with a high risk of infection and for patients with a reduced host resistance to bacterial infection. Vericef should be administered immediately prior to surgery in order to ensure sufficient local tissue concentrations at the time that contamination is likely to occur. Treatment should be continued during the post-operative period.

Adults:

Respiratory tract infections and skin and soft tissue infections: The usual dose is 250 mg or 500 mg four times daily or 500 mg or 1 g twice daily depending on the severity and site of infection.

Urinary tract infections: The usual dose is 500 mg four times daily or 1 g twice daily. This may need to be increased for severe or chronic infections. Prolonged intensive therapy is needed for complications such as prostatitis and epididymitis.

Children’s:

The usual dose is 25 to 50 mg/kg/day, given in two or four equally divided doses. For otitis media daily doses from 75 to 100 mg/kg in divided doses every 6 to 12 hours are recommended. Maximum dose 4 g per day. Cefradine may be taken without regard to meals.

Elderly:

As for adult patients with impaired renal or hepatic function should be monitored as modifications of the dosage schedule may be required.

Dosage in renal impairment:

A modified dosage schedule is necessary in patients with decreased renal function. Each patient should be considered individually. The following modified dosage schedule is recommended as a guideline, based on creatinine clearance. In adults, the initial loading dose is 750 mg of Cefradine and the maintenance dose is 500 mg at the following intervals:

Creatinine clearance & Time intervals:

• More than 20 ml/min, 6-12 hours
• 15-19 ml/min, 12-24 hours
• 10-14 ml/min, 24-40 hours
• 5-9 ml/min, 40-50 hours
• Less than 5 ml/min, 50-70 hours